LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels
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چکیده
منابع مشابه
SOX2 regulates the hypothalamic-pituitary axis at multiple levels.
Sex-determining region Y (SRY) box 2 (SOX2) haploinsufficiency causes a form of hypopituitarism in humans that is characterized by gonadotrophin deficiency known as hypogonadotrophic hypogonadism. Here, we conditionally deleted Sox2 in mice to investigate the pathogenesis of hypogonadotrophic hypogonadism. First, we found that absence of SOX2 in the developing Rathke pouch of conditional embryo...
متن کاملEffects of Crocin on The Pituitary-Gonadal Axis and Hypothalamic Kiss-1 Gene Expression in Female Wistar Rats
Background: Saffron (Crocus sativus L.) is traditionally used as a spice for coloring and flavoring in cooking in some countries. One of the main component of saffron is Crocin. Recent researches have shown Crocin has various pharmacological effects. The aim of this study was to assess the effect of Crocin on the Pituitary-Gonadal Axis and Kiss-1 gene expression in hypothalamus and also ovarian...
متن کاملStress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression.
We have previously reported that inescapable tail shock (IS) produces persistent changes in hypothalamic-pituitary-adrenal (HPA) axis function. These changes are manifest as an elevation in basal corticosterone (CORT) levels, a sensitization of adrenocorticotropin hormone (ACTH) and CORT responses to subsequent challenge, and a failure of dexamethasone to suppress both the ACTH and CORT respons...
متن کاملMethamphetamine and the hypothalamic-pituitary-adrenal axis
Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the ...
متن کاملAbnormalities at different levels of the hypothalamic-pituitary-adrenocortical axis early after stroke.
BACKGROUND AND PURPOSE Hypercortisolism is common in stroke patients. The aim of this study was to investigate possible disturbances at different sites within the hypothalamic-pituitary-adrenal axis. We also studied possible associations between hypercortisolism and clinical manifestations of brain dysfunction. METHODS Patients with an acute ischemic stroke (n = 16; mean +/- SD age, 71 +/- 11...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-54475-6